Miquel Bosch, Ph.D. Post-doctoral Fellow e-mail tel 617-324-7008

Research interests                                       

I’m interested in the experience-dependent changes that occur in the nervous system during development, learning and memory at the most fundamental level: the individual synapse. I use two-photon excitation microscopy to visualize the selective changes that take place in the structure and the molecular composition of cortical and hippocampal dendritic spines associated to events of synaptic plasticity such as LTP and LTD.


Publications                                           

Okamoto K.*, Bosch M.*, Hayashi Y. (*Equal contribution). The roles of CaMKII and F-actin in the structural plasticity of dendritic spines  – a potential molecular identity of a synaptic tag?  Physiology (2009). Review in press.

Hirokawa J., Bosch M., Sakata S., Sakurai Y., Yamamori T. Functional Role of the Secondary Visual Cortex in Multisensory Facilitation in Rats. Neuroscience, Jun 2008, 153(4):1402-17

Bosch M.*, Ginés S.*, Marco S., Gavaldà N., Díaz-Hernández M., Lucas J.J., Canals J.M., Alberch J. (*Equal contribution).  Reduced Expression of theTrkB Receptor in Huntington's Disease Mouse Models and in Human Brain.  European Journal of Neuroscience, Feb 2006, 23(3):649-58.

Orive G., De Castro M., Ponce S., Hernandez R.M., Gascon A.R., Bosch M., Alberch J.,  Pedraz J.L.  Long-Term Expression of Erythropoietin from Myoblasts Immobilized in Biocompatible and Neovascularized Microcapsules.  Molecular Therapy, Aug 2005, 12 (2):283-9.

Pineda J.R., Canals J.M., Bosch M., Adell A., Mengod G., Artigas F., Ernfors P., Alberch J.  Brain-Derived Neurotrophic Factor Modulates Dopaminergic Deficits in a Transgenic Mouse Model of Huntington’s Disease.  The Journal of Neurochemistry, Jun 2005, 93(5):1057-68.

Bosch M., Pineda J.R., Suñol C., Petriz J., Cattaneo E., Alberch J., Canals J.M.  Induction of GABAergic Phenotype in a Neural Stem Cell Line for Transplantation in an Excitotoxic Model of Huntington's Disease.  Experimental Neurology, Nov 2004, 190(1):42-58.

Canals J.M., Pineda J.R., Torres-Peraza J.F., Bosch M., Martín-Ibañez R., Muñoz M.T., Mengod G., Ernfors P., Alberch J.  Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease.  The Journal of Neuroscience, Sep 2004, 24(35):7727-7739.


Education/Training                                       

Postdoctoral fellow at Mark F. Bear Lab. The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. (Aug 2009 – present)

Postdoctoral fellow at Yasunori Hayashi Lab, RIKEN-MIT Neuroscience Research Centre, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology., Cambridge, MA, USA (Nov 2005-Jul 2009).

Postdoctoral associate at Tetsuo Yamamori Lab, Division of Brain Biology, National Institute for Basic Biology, Okazaki, Japan (May-Oct 2005).

Ph.D. in Neuroscience. Medical School, University of Barcelona, Barcelona, Spain (Aug 2000-Apr 2005). Supervisors: Dr. Jordi Alberch and Dr. Josep M. Canals. Thesis title: Cell therapy in Huntington's disease models.

B.S. in Biochemistry. Faculty of Biology, University of Barcelona, Barcelona, Spain (Feb 2000).