Jason Coleman, Ph.D. Post-Doctoral Fellow e-mail tel: 617-324-7006; 617-324-7010 Personal webpage

Research Interests
My research interests are focused on understanding the anatomical basis for experience-dependent alterations in synaptic strength. In my research, I am combining molecular- and viral vector-based techniques with state-of-the-art imaging technologies to trace and track neurons in the primary visual pathway - a classic model for studies of experience-dependent plasticity.

Publications
Williams ME*, Coleman JE*, Haire S, Aleman T, Cideciyan A, Sokal I, Palczewski K, Jacobson SG (2006).
Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision in an Avian Model of Childhood Blindness.
PLoS Med. 3(6):e201.
*Equal contribution
open access - http://dx.doi.org/10.1371/journal.pmed.0030201

Coleman JE and Semple-Rowland SL. (2005).
GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells.
Invest. Ophthalmol. Vis Sci. 100(2), 367-72. [PDF]

Coleman JE, Wu K, Fülle H-J and Semple-Rowland SL (2004).
The 5' flanking sequence of the human retGC1 gene acquires a photoreceptor cell-restricted activity pattern over the course of retinal development.
Mol. Vision 10, 720-727
open access - http://www.molvis.org/molvis/v10/a87/

Coleman JE, Zhang Y, Brown GAJ and Semple-Rowland SL (2004).
Cone cell survival and downregulation of GCAP1 protein in the retinas of GC1 knockout mice.
Invest. Ophthalmol. Vis Sci. 45(10), 3397-403 [PDF].

Zhang,Y, Coleman JE, Fuchs GE, Semple-Rowland SL (2003).
Circadian oscillator function in embryonic retina and retinal explant cultures.
Brain Res. Mol. Brain Res. 114, 9-19.

Coleman JE*, Huentelman MJ*, Kasparov S, Metcalfe BL, Paton JFR, Katovich MJ, Semple-Rowland SL and Raizada MK (2003).
Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo.
Physiol. Genomics 12, 221-228.
*Equal contribution

Coleman JE, Fuchs GE and Semple-Rowland SL (2002).
Analyses of the guanylate cyclase activating protein –1 (GCAP1) promoter in the developing retina.
Invest. Ophthalmol. Vis Sci. 43(5):1335-43. [PDF]

Semple-Rowland SL, Tepedino M, and Coleman JE (2001).
Pinopsin mRNA levels are significantly elevated in the pineal glands of chickens carrying a null mutation in guanylate cyclase – 1.
Brain Res. Mol. Brain Res. 97(1):51-8.

Jones HC, Rivera KM and Coleman JE (1996).
Spatial learning and visual discrimination tests in hydrocephalic rat pups performed using the Morris water maze.
European Journal of Pediatric Surgery 6, 37.