Howard Hughes Medical Institute :: MIT :: The Picower Institute for Learning and Memory
 |
Dilja Krueger, Ph.D. Post-Doctoral Fellow tel 617-324-7010
|
Research interests
My research is aimed at investigating the molecular mechanisms underlying neurodevelopmental disorders related to autism. In particular, I am interested in understanding how loss of the protein FMRP results in fragile X syndrome, the most common inherited form of mental retardation and a known cause of autistic behaviors. Using a combination of biochemical and behavioral approaches, I am studying the molecular function of FMRP in neurons and the mechanisms by which the absence of FMRP affects synapses and cognitive function in rodents.
Education
2001-2007 Ph.D., Yale University (interdepartmental neuroscience program)
1997-2001 M.Biochem, Oxford University (undergraduate degree in biochemistry)
Publications
Krueger DD and Nairn AC (2007) Expression of PKC substrate proteins GAP-43 and neurogranin is down-regulated by cAMP signaling and alterations in synaptic activity. Eur J Neurosci. 26:3043-53
Olausson P, Jentsch JD, Krueger DD, Tronson NC, Nairn AC and Taylor JR (2007) Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: Evidence from experiments in the non-human primate.
Ann N Y Acad Sci. 1121:610-38
Andrade EC, Krueger DD and Nairn AC (2007) Recent advances in neuroproteomics.
Curr Opin Mol Ther. 9(3):270-81 (Review)
Krueger DD, Howell JL, Fabacher B, Olausson P, Taylor JR and Nairn AC (2006) Assessment of cognitive function in the heterozygous reeler mouse. Psychopharmacology 189:95-104
Slager EH, van der Minne CE, Kruse M, Krueger DD, Griffioen M & Osanto S (2004) Identification of Multiple HLA-DR-Restricted Epitopes of the Tumor-Associated Antigen CAMEL by CD4(+) Th1/Th2 Lymphocytes.
J Immunol. 172:5095-102
Wang DD, Krueger DD & Bordey A (2003) GABA depolarizes neuronal progenitors of the postnatal subventricular zone via GABAA receptor activation. J Physiol. 550:785-800
Wang DD, Krueger DD & Bordey A (2003) Biophysical properties and ionic signature of neuronal progenitors of the postnatal subventricular zone in situ. J Neurophysiol. 90:2291-302