Howard Hughes Medical Institute :: MIT :: The Picower Institute for Learning and Memory

Sam Cooke, Ph.D.

Post-Doctoral Fellow


tel 617-324-7006



1993-1996 – Bachelor of Arts, Philosophy and Psychology. The University of Sheffield, United Kingdom.

1997-1998 – Research Masters, Neurological Science. Department of Anatomy and Developmental Biology, University College London (UCL), UK.

1998-2002  PhD, Behavioural Neuroscience. Department of Anatomy and Developmental Biology, University College London (UCL), UK.


Plattner F, Hernandez A, Kistler TM, Pozo K, Zhong P, Yuen, EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA (2014) Memory Enhancement by Targeting Cdk5 Regulation of NR2B. Neuron. 81(5):1079-1083.

Cooke SF and Bear MF (2013) How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex. Philosophical Transactions of the Royal Society (London) B Biological Sciences. 369(1633):20130284.

Cooke SF and Bear MF (2012) Stimulus-selective response plasticity in the visual cortex: An assay for the assessment of pathophysiology and treatment of cognitive impairment associated with psychiatric disorders. Biologicial Psychiatry. 71(6):487:95.

Bliss TVP and Cooke SF (2011) What are the clinical applications of long-term potentiation (LTP) and depression (LTD)? Clinics. 66 Suppl. 1:3-17.

Cooke SF and Bear MF (2010) Visual experience induces long-term potentiation in the primary visual cortex. Journal of Neuroscience. 30(48):16304-13.

Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz VL, Bliss TV (2008) Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learning and Memory. 15(7):492-500.

Neves G, Cooke SF, Bliss TV (2008) Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nature Reviews Neuroscience. 9(1): 65-75.

Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S (2007) Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. European Journal of Neuroscience. 25(1): 81-86.

Plath N, Ohana O, Dammermann B, Errington ML, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Fernandez E, Husi H, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bösl MR, Lipp HP, Schmitz D, Grant SGN, Bliss TVP, Wolfer DP, Kuhl D (2006) Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron. 52(3):437-44.

Cooke SF*, Wu J*, Plattner F*, Errington M, Rowan M, Peters M, Hirano A, Bradshaw KD, Anwyl R, Bliss TVP and Giese KP (2006) Autophosphorylation of _lphaCaMKII is not a general effector mechanism for NMDA-dependent long-term potentiation in the adult mouse. Journal of Physiology. 574.3: 805-18. *equal contributors.

Cooke SF and Bliss TVP (2006) Plasticity in the human nervous system. Brain. 129 (7): 1659-73.

O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, Nizetic D, Tybulewicz VL, Fisher EM (2005) An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science. 309 (5743): 2033-7.

Fragkouli F, Hearn C, Errington M, Cooke S, Grigoriou M, Bliss T, Stylianopoulou F and Pachnis V (2005) Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. European Journal of Neuroscience. 21(11): 2923-38.

Cooke SF and Bliss TVP (2005) Long-term potentiation and cognitive drug discovery. Current opinion in drug discovery. 6(1): 25-34.

Cooke SF, Attwell PJ and Yeo CH (2004) Temporal properties of cerebellar-dependent memory consolidation. Journal of Neuroscience. 24: 2934-41.

Cooke SF and Bliss TVP (2003) The genetic enhancement of memory. Cellular and Molecular Life Sciences. 60: 1-5.

Attwell PJ, Cooke SF and Yeo CH (2002) Cerebellar function in consolidation of a motor memory Neuron. 34: 1011-20.

Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W and Rosenthal A (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Developmental biology. 208: 473-87.


l> ody> dy> ml> ml>