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Berry-Kravis E, Hagerman R, Visootsak J, Budimirovic D, Kaufmann WE, Cherubini M, Zarevics P, Walton-Bowen K, Wang P, Bear MF, Carpenter RL. Arbaclofen in fragile X syndrome: results of phase 3 trials.
J Neurodev Disord. 2017 Jun 12;9:3.

Stoppel LJ, Auerbach BD, Senter RK, Preza AR, Lefkowitz RJ, Bear MF. β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.
Cell Rep. 2017 Mar 21;18(12):2807-2814.

Tao J, Wu H, Coronado AA, de Laittre E, Osterweil EK, Zhang Y, Bear MF.
Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome.
J Neurosci. 2016 Nov 23;36(47):11946-11958

Fong MF, Mitchell DE, Duffy KR, Bear MF.
Rapid recovery from the effects of early moncular deprivation is enabled by temporary inactivation of the retinas.
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14139-14144

Veenstra-VanderWeele J, Cook EH, King BH, Zarevics P, Cherubini M, Walton-Bowen K, Bear MF, Wang PP, Carptenter RL.
Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trail.

Neuropsychopharmacology. 2016 Nov 9. EPub ahead of print.

Kaplan ES, Cooke SF, Komorowski RW, Chubykin AA, Thomazeau A, Khibnik LA, Gavornik JP, Bear MF
Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity
eLife. 2016 Mar 4;5. pii: e11450

Prilutsky D, Kho AT, Palmer NP, Bhakar AL, Smedemark-Margulies N, Kong SW, Margulies DM, Bear MF, Kohane IS
Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures
Mol Autism. 2015 Dec 21;6:66

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ
Convergence of Hippocampal Pathophysiology in Syngap(+/-) and Fmr1(-/y) Mice
J Neurosci. 2015 Nov 11;35(45):15073-81

Sidorov MS, Kaplan ES, Osterweil EK, Lindemann L, Bear MF
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7

Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC
Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS
Hum Mol Genet. 2015 Nov 1;24(21):5977-84

Cooke SF, Bear MF
Visual recognition memory: a view from V1
Curr Opin Neurobiol. 2015 Jul 4;35:57-65

Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF
Visual recognition memory, manifested as long-term habituation, requires
synaptic plasticity in V1

Nat Neurosci. 2015 Jan 19 [Epub ahead of print]

Tian D, Stoppel LJ, Heynen AJ, Lindemann L, Jaeschke G, Mills AA, Bear MF
Contribution of mGluR5 to pathophysiology in a mouse model of human
chromosome 16p11.2 microdeletion

Nat Neurosci. 2015 Jan 12 [Epub ahead of print]

Sidorov MS, Krueger DD, Taylor M, Gisin E, Osterweil EK, Bear MF
Extinction of an instrumental response: A cognitive behavioral assay in Fmr1 knockout mice
Genes Brain Behav. 2014 Mar 31 [Epub ahead of print]

Gavornik JP, Bear MF
Learned spatiotemporal sequence recognition and prediction in primary visual cortex
Nat Neurosci. 2014 May;17(5):732-7

Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D,
Bear MF, Kunkel LM, Kohane IS
Divergent dysregulation of gene expression in murine models of fragile X syndrome
and tuberous sclerosis

Mol Autism. 2014 Feb 24;5(1):16

Cooke SF, Bear MF
How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130284

Erickson CA, Veenstra-Vanderweele JM, Melmed RD, McCracken JT, Ginsberg LD, Sikich L, Scahill L, Cherubini M, Zarevics P, Walton-Bowen K, Carpenter RL, Bear MF, Wang PP, King BH
STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study
J Autism Dev Disord. 2013 Nov 23. [Epub ahead of print]

Lohith TG, Osterweil EK, Fujita M, Jenko KJ, Bear MF, Innis RB
Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
Mol Autism. 2013 May 24;4(1):15

Sidorov MS, Auerbach BD, Bear MF
Fragile X mental retardation protein and synaptic plasticity
Mol Brain. 2013 Apr 8;6:15

Chubykin AA, Roach EB, Bear MF, Shuler MG
A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex
Neuron. 2013 Feb 20;77(4):723-35

Osterweil EK, Chuang SC, Chubykin AA, Sidorov M, Bianchi R, Wong RK, Bear MF
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile x syndrome
Neuron. 2013 Jan 23;77(2):243-50

Osterweil EK, Kind PC, Bear MF
Lifting the Mood on Treating Fragile X
Biol Psychiatry. 2012 Dec 1;72(11):895-7

Cooper LN, Bear MF
The BCM theory of synapse modification at 30: interaction of theory with experiment
Nat Rev Neurosci. 2012 Nov;13(11):798-810

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, ... , Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM
Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen
Sci Transl Med. 2012 Sep 19;4(152):152ra128

Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen DV, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, Hagerman RJ
Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial
Sci Transl Med. 2012 Sep 19;4(152):152ra127

Michalon A, Sidorov M, Ballard TM, Ozmen L, Spooren W, Wettstein JG, Jaeschke G, Bear MF, Lindemann L
Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
Neuron. 2012 Apr 12;74(1):49-56

Bhakar AL, Dölen G, Bear MF
The pathophysiology of fragile X (and what it teaches us about synapses)
Annu Rev Neurosci. 2012;35:417-43 Epub 2012 Apr 5

Zoghbi HY, Bear MF
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities
Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). Review

Auerbach BD, Osterweil EK, Bear MF
Mutations causing syndromic autism define an axis of synaptic pathophysiology
Nature. 2011 Nov 23;480(7375):63-68

Rachmuth G, Shouval HZ, Bear MF, Poon CS
A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49)

Cooke SF, Bear MF
Stimulus-Selective Response Plasticity in the Visual Cortex: An Assay for the Assessment of Pathophysiology and Treatment of Cognitive Impairment Associated with Psychiatric Disorders
Biol Psychiatry. 2011 Oct 19. [Epub ahead of print]

Javitt DC, Schoepp D, Kalivas PW, Volkow ND, Zarate C, Merchant K, Bear MF, Umbricht D, Hajos M, Potter WZ, Lee CM
Translating glutamate: from pathophysiology to treatment
Sci Transl Med. 2011 Sep 28;3(102):102mr2

Shepherd JD, Bear MF
New views of Arc, a master regulator of synaptic plasticity

Nat Neurosci. 2011 Mar;14(3):279-84

Krueger DD, Osterweil EK, Chen SP, Tye LD, Bear MF
Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2587-92

Cooke SF, Bear MF
Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex
J Neurosci. 2010 Dec 1;30(48):16304-13

Krueger DD, Bear MF
Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome
Annu Rev Med. 2011;62:411-29

Osterweil EK, Krueger DD, Reinhold K, Bear MF
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
J Neurosci. 2010 Nov 17;30(46):15616-27

Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, ... , Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM
Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment
Brain Res. 2011 Mar 22;1380:106-19

Coleman JE, Nahmani M, Gavornik JP, Haslinger R, Heynen AJ, Erisir A, Bear MF
Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex
J Neurosci. 2010 Jul 21;30(29):9670-82

Smith GB, Bear MF
Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions
Front Cell Neurosci. 2010 Jun 17;4:21

Auerbach BD, Bear MF
Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis
J Neurophysiol. 2010 Aug;104(2):1047-51

Khibnik LA, Cho KK, Bear MF
Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
Neuron. 2010 May 27;66(4):493-500

Dölen G, Carpenter RL, Ocain TD, Bear MF
Mechanism-based approaches to treating fragile X
Pharmacol Ther. 2010 Jul;127(1):78-93

McCurry CL, Shepherd JD, Tropea D, Wang KH, Bear MF, Sur M
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
Nat Neurosci. 2010 Apr;13(4):450-7

Cho KK, Bear MF
Promoting neurological recovery of function via metaplasticity
Future Neurol. 2010 Jan 1;5(1):21-26

Krueger DD, Osterweil EK, Bear MF
Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons

J Mol Neurosci. 2010 Sep;42(1):1-8. Epub 2010 Feb 23

2000-2009     [back to top]

Morrow SA, Kaushik T, Zarevics P, Erlanger D, Bear MF, Munschauer FE, Benedict RH
The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial
J Neurol. 2009 Jul;256(7):1095-102

Wiig KA, Whitlock JR, Epstein MH, Carpenter RL, Bear MF
The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation
Neurobiol Learn Mem. 2009 Jul;92(1):106-13

Coleman JE, Law K, Bear MF
Anatomical origins of ocular dominance in mouse primary visual cortex
Neuroscience. 2009 Jun 30;161(2):561-71

Yoon BJ, Smith GB, Heynen AJ, Neve RL, Bear MF
Essential role for a long-term depression mechanism in ocular dominance plasticity
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9860-5

Gavornik JP, Shuler MG, Loewenstein Y, Bear MF, Shouval HZ
Learning reward timing in cortex through reward dependent expression of synaptic plasticity
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6826-31

Linden ML, Heynen AJ, Haslinger RH, Bear MF
Thalamic activity that drives visual cortical plasticity
Nat Neurosci. 2009 Apr;12(4):390-2

Cho KK, Khibnik L, Philpot BD, Bear MF
The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5377-82

Smith GB, Heynen AJ, Bear MF
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67

Lee S, Kim W, Ham BJ, Chen W, Bear MF, Yoon BJ
Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation
Biochem Biophys Res Commun. 2008 Dec 19;377(3):930-4

Kelleher RJ 3rd, Bear MF
The autistic neuron: troubled translation?
Cell. 2008 Oct 31;135(3):401-6

Blais BS, Frenkel MY, Kuindersma SR, Muhammad R, Shouval HZ, Cooper LN, Bear MF
Recovery from monocular deprivation using binocular deprivation
J Neurophysiol. 2008 Oct;100(4):2217-24

Liu CH, Heynen AJ, Shuler MG, Bear MF
Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex
Neuron. 2008 May 8;58(3):340-5

Dölen G, Bear MF
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
J Physiol. 2008 Mar 15;586(6):1503-8

Hung AY, Futai K, Sala C, Valtschanoff JG, Ryu J, Woodworth MA, Kidd FL, Sung CC, 
Miyakawa T, Bear MF, Weinberg RJ, Sheng M
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1
J Neurosci. 2008 Feb 13;28(7):1697-708

Bear MF, Dölen G, Osterweil E, Nagarajan N
Fragile X: translation in action
Neuropsychopharmacology. 2008 Jan;33(1):84-7

Dölen G, Osterweil E, Rao BS, Smith GB, Auerbach BD, Chattarji S, Bear MF.
Correction of fragile X syndrome in mice
Neuron. 2007 Dec 20;56(6):955-62

Catania MV, D'Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F
Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders?
Mol Neurobiol. 2007 Jun;35(3):298-307

Philpot BD, Cho KK, Bear MF
Obligatory Role of NR2A for Metaplasticity in Visual Cortex
Neuron. 2007 Feb 15;53(4):495-502

Crozier RA, Wang Y, Liu CH, Bear MF
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1383-8

Whitlock JR, Heynen AJ, Shuler MG, Bear MF
Learning induces long-term potentiation in the hippocampus
Science. 2006 Aug 25;313(5790):1093-7

Morishita W, Lu W, Smith GB, Nicoll RA, Bear MF, Malenka RC
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
Neuropharmacology, 2007 Jan; 52(1): 71-6

Chen WS, Bear MF
Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex
Neuropharmacology 2007 Jan; 52(1): 200-14

Frenkel MY, Sawtell NB, Diogo AC, Yoon B, Neve RL, Bear MF
Instructive effect of visual experience in mouse visual cortex
Neuron. 2006 Aug 3;51(3):339-49

Iny K, Heynen AJ, Sklar E, Bear MF
Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and  adult rats

J Neurosci. 2006 Jul 12;26(28):7368-74

Rittenhouse CD, Siegler BA, Voelker CA, Shouval HZ, Paradiso MA, Bear MF
The Stimulus for Rapid Ocular Dominance Plasticity in Visual Cortex
J Neurophysiol. 2006 May; 95(5): 2947-50

Shuler MG, Bear MF
Reward timing in the primary visual cortex
Science. 2006 Mar 17;311(5767):1606-9

Bear MF
Therapeutic implications of the mGluR theory of fragile X mental retardation
Genes Brain Behav. 2005 Aug;4(6):393-8

Dölen G, Bear MF
Courting a cure for fragile X
Neuron. 2005 Mar 3;45(5):642-4

Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression
J Biol Chem. 2005 Apr 29;280(17):16962-8

Frenkel MY, Bear MF
How monocular deprivation shifts ocular dominance in visual cortex of young mice
Neuron. 2004 Dec 16;44(6):917-23

Malenka RC, Bear MF
LTP and LTD: an embarrassment of riches
Neuron. 2004 Sep 30;44(1):5-21

Wallace W, Bear MF
A morphological correlate of synaptic scaling in visual cortex
J. Neurosci. 2004 Aug; 24(31):6928-6938

Bear MF, Huber KM, Warren ST
The mGluR theory of fragile x mental retardation
Trends in Neuroscience 2004 Jul; 27(7): 370-377

Nahm WK, Philpot BD, Adams MM, Badiavas EV, Zhou LH, Butmarc J, Bear MF, Falanga V
Significance of N-methyl-D-(NMDA) receptor-mediated signaling in human keratinocytes
J. Cellular Physiology 2004 Aug; 200(2):309-17

Gallagher SM, Daly CA, Bear MF, Huber KM
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1
J Neurosci. 2004 May 19; 24(20):4859-64

Jackson JD, Yezzi AJ, Wallace W, Bear MF
Segmentation of coarse and fine scale features using multi-scale diffusion and Mumford-Shah
Lecture Notes in Computer Science. 2003;2695:615-624

Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF, Scott JD
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression
Neuron. 2003 Oct 30;40(3):595-607

Heynen AJ, Yoon B-J, Liu C-H, Chung HJ, Huganir RL, Bear MF
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
Nat Neurosci. 2003 Aug;6(8):854-862

Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF
NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex
Neuron. 2003 Jun 19;38(6):977-85

Bear MF
Bidirectional synaptic plasticity: from theory to reality
Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):649-55

Shouval HZ, Bear MF, Cooper LN
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
Proc Natl Acad Sci U S A. 2002 Jul 22

Huber KM, Gallagher SM, Warren ST, Bear MF
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50

Philpot BD, Bear MF
Synaptic plasticity in an altered state
Neuron. 2002 Feb 28;33(5):665-7

Heynen AJ, Bear MF
Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo
J Neurosci. 2001 Dec 15;21(24):9801-13

Wells DG, Dong X, Quinlan EM, Huang YS, Bear MF, Richter JD, Fallon JR
A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA  translation in neurons
J Neurosci. 2001 Dec 15;21(24):9541-8

Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S 
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory
Cell. 2001 Nov 30;107(5):617-29

Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, Bear MF
Internalization of ionotropic glutamate receptors in response to mGluR activation
Nat Neurosci. 2001 Nov;4(11):1079-85

Philpot BD, Weisberg MP, Ramos MS, Sawtell NB, Tang YP, Tsien JZ, Bear MF
Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex
Neuropharmacology. 2001 Nov;41(6):762-70

Abraham WC, Mason-Parker SE, Bear MF, Webb S, Tate WP
Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10924-9

Rozas C, Frank H, Heynen AJ, Morales B, Bear MF, Kirkwood A
Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex
J Neurosci. 2001 Sep 1;21(17):6791-801

Huber KM, Roder JC, Bear MF
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1
J Neurophysiol. 2001 Jul;86(1):321-5

Philpot BD, Sekhar AK, Shouval HZ, Bear MF
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex
Neuron. 2001 Jan;29(1):157-69. Shouval HZ, Bear MF, Cooper LN

Heynen AJ, Quinlan EM, Bae DC, Bear MF
Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo
Neuron. 2000 Nov;28(2):527-36

Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Nature. 2000 Jun 22;405(6789):955-9

Huber KM, Kayser MS, Bear MF
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term  depression
Science. 2000 May 19;288(5469):1254-7

1990-1999    [back to top]

Bear MF, Colman H
Binocular competition in the control of geniculate cell size depends upon visual cortical N-methyl-D-aspartate receptor activation
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9246-9

Barstad KE, Bear MF
Basal forebrain projections to somatosensory cortex in the cat
J Neurophysiol. 1990 Oct;64(4):1223-32

Juliano SL, Ma W, Bear MF, Eslin D
Cholinergic manipulation alters stimulus-evoked metabolic activity in cat somatosensory cortex
J Comp Neurol. 1990 Jul 1;297(1):106-20

Bear MF, Kleinschmidt A, Gu QA, Singer W
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist
J Neurosci. 1990 Mar;10(3):909-25

Feldman D, Sherin JE, Press WA, Bear MF
N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro
Exp Brain Res. 1990;80(2):252-9

Clothiaux EE, Bear MF, Cooper LN
Synaptic plasticity in visual cortex: comparison of theory with experiment
J Neurophysiol. 1991 Nov;66(5):1785-804

Alkon DL, Amaral DG, Bear MF, Black J, Carew TJ, Cohen NJ, Disterhoft JF, Eichenbaum H, et al. 
Learning and memory. FESN Study Group
Brain Res Brain Res Rev. 1991 May-Aug;16(2):193-220

Reynolds IJ, Bear MF
Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten  visual cortex
Exp Brain Res. 1991;85(3):611-5

Bear MF, Dudek SM
Stimulation of phosphoinositide turnover by excitatory amino acids: Pharmacology,  development, and role in visual cortical plasticity
Ann N Y Acad Sci. 1991;627:42-56

Bohner AP, Dudek SM, Bear MF
Effects of N-methyl-D-aspartate on quisqualate-stimulated phosphoinositide hydrolysis in slices  of kitten striate cortex
Brain Res. 1992 Oct 23;594(1):146-9

Dudek SM, Bear MF
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4363-7

Bear MF, Press WA, Connors BW
Long-term potentiation in slices of kitten visual cortex and the effects of NMDA receptor blockade
J Neurophysiol. 1992 Apr;67(4):841-51

Dudek SM, Bear MF
Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus
J Neurosci. 1993 Jul;13(7):2910-8

Kirkwood A, Dudek SM, Gold JT, Aizenman CD, Bear MF
Common forms of synaptic plasticity in the hippocampus and neocortex in vitro
Science. 1993 Jun 4;260(5113):1518-21

Bear MF, Kirkwood A
Neocortical long-term potentiation
Curr Opin Neurobiol. 1993 Apr;3(2):197-202

Bear MF, Malenka RC
Synaptic plasticity: LTP and LTD
Curr Opin Neurobiol. 1994 Jun;4(3):389-99

Kirkwood A, Bear MF
Homosynaptic long-term depression in the visual cortex
J Neurosci. 1994 May;14(5 Pt 2):3404-12

Gold JI, Bear MF
A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3941-5

Kirkwood A, Bear MF
Hebbian synapses in visual cortex
J Neurosci. 1994 Mar;14(3 Pt 2):1634-45

Law CC, Bear MF, Cooper LN
Role of the visual environment in the formation of receptive fields according to the BCM theory
Prog Brain Res. 1994;102:287-301

Selig DK, Lee HK, Bear MF, Malenka RC
Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation
J Neurophysiol. 1995 Sep;74(3):1075-82

Bear MF
Mechanism for a sliding synaptic modification threshold
Neuron. 1995 Jul;15(1):1-4

Kirkwood A, Lee HK, Bear MF
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience
Nature. 1995 May 25;375 (6529):328-31

Kirkwood A, Bear MF
Elementary forms of synaptic plasticity in the visual cortex
Biol Res. 1995;28(1):73-80

Bear MF
A synaptic basis for memory storage in the cerebral cortex
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13453-9

Aizenman CD, Kirkwood A, Bear MF
A current source density analysis of evoked responses in slices of adult rat visual cortex: implications for the regulation of long-term potentiation
Cereb Cortex. 1996 Nov-Dec;6(6):751-8

Kirkwood A, Rioult MC, Bear MF
Experience-dependent modification of synaptic plasticity in visual cortex
Nature. 1996 Jun 6;381(6582):526-8

Heynen AJ, Abraham WC, Bear MF
Bidirectional modification of CA1 synapses in the adult hippocampus in vivo
Nature. 1996 May 9;381(6578):163-6

Abraham WC, Bear MF
Metaplasticity: the plasticity of synaptic plasticity
Trends Neurosci. 1996 Apr;19(4):126-30

Bear MF
Progress in understanding NMDA-receptor-dependent synaptic plasticity in the visual cortex
J Physiol Paris. 1996;90(3-4):223-7

Bear MF
NMDA-receptor-dependent synaptic plasticity in the visual cortex
Prog Brain Res. 1996;108:205-18

Bear MF, Abraham WC
Long-term depression in hippocampus
Annu Rev Neurosci. 1996;19:437-62

Wiig KA, Cooper LN, Bear MF
Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat
Learn Mem. 1996 Nov-Dec;3(4):313-25

Kirkwood A, Silva A, Bear MF
Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3380-3

Bear MF
How do memories leave their mark? 
Nature. 1997 Feb 6;385(6616):481-2

Kameyama K, Lee HK, Bear MF, Huganir RL
Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression
Neuron. 1998 Nov;21(5):1163-75

Lee HK, Kameyama K, Huganir RL, Bear MF
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus
Neuron. 1998 Nov;21(5):1151-62

Huber KM, Sawtell NB, Bear MF
Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex
Neuropharmacology. 1998 Apr-May;37(4-5):571-9

Huber KM, Sawtell NB, Bear MF
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex
J Neurosci. 1998 Jan 1;18(1):1-9

Sawtell NB, Huber KM, Roder JC, Bear MF
Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors
J Neurophysiol. 1999 Dec;82(6):3594-7

Quinlan EM, Olstein DH, Bear MF
Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12876-80

Bear MF, Rittenhouse CD
Molecular basis for induction of ocular dominance plasticity
J Neurobiol. 1999 Oct;41(1):83-91

Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S
BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
Cell. 1999 Sep 17;98(6):739-55

Bear MF
Homosynaptic long-term depression: a mechanism for memory? 
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9457-8

Quinlan EM, Philpot BD, Huganir RL, Bear MF
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Nat Neurosci. 1999 Apr;2(4):352-7

Taubenfeld SM, Wiig KA, Bear MF, Alberini CM
A molecular correlate of memory and amnesia in the hippocampus
Nat Neurosci. 1999 Apr;2(4):309-10

Kirkwood A, Rozas C, Kirkwood J, Perez F, Bear MF
Modulation of long-term synaptic depression in visual cortex by acetylcholine and  norepinephrine
J Neurosci. 1999 Mar 1;19(5):1599-609

Rittenhouse CD, Shouval HZ, Paradiso MA, Bear MF
Monocular deprivation induces homosynaptic long-term depression in visual cortex
Nature. 1999 Jan 28;397(6717):347-50

1980-1989    [back to top]

Carey RG, Bear MF, Diamond IT
The laminar organization of the reciprocal projections between the claustrum and striate cortex 
in the tree shrew, Tupaia gli
Brain Res. 1980 Feb 17;184(1):193-8

Bear MF, Ebner FF
Somatostatin-like immunoreactivity in the forebrain of Pseudemys turtles
Neuroscience. 1983 Jun; 9(2):297-307

Bear MF, Paradiso MA, Schwartz M, Nelson SB, Carnes KM, Daniels JD
Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity
Nature. 1983 Mar 17-23;302(5905):245-7

Bear MF, Daniels JD
The plastic response to monocular deprivation persists in kitten visual cortex after chronic depletion of norepinephrine
J Neurosci. 1983 Feb;3(2):407-16

Haycock DA, Bear MF
The stability of 6-hydroxydopamine under minipump conditions
Exp Brain Res. 1984;56(1):183-6

Bear MF, Carnes KM, Ebner FF
Postnatal changes in the distribution of acetylcholinesterase in kitten striate cortex
J Comp Neurol. 1985 Jul 22;237(4):519-32

Bear MF, Schmechel DE, Ebner FF
Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens
J Neurosci. 1985 May;5(5):1262-75

Hohmann CF, Bear MF, Ebner FF
Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain
Brain Res. 1985 Apr 29;333(1):165-8

Bear MF, Carnes KM, Ebner FF
An investigation of cholinergic circuitry in cat striate cortex using acetylcholinesterase histochemistry
J Comp Neurol. 1985 Apr 22;234(4):411-30

Bear MF, Singer W
Modulation of visual cortical plasticity by acetylcholine and noradrenaline
Nature. 1986 Mar 13-19;320(6058):172-6

Kleinschmidt A, Bear MF, Singer W
Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex
Science. 1987 Oct 16;238(4825):355-8

Bear MF, Cooper LN, Ebner FF
A physiological basis for a theory of synapse modification
Science. 1987 Jul 3;237(4810):42-8

Bear MF, Kleinschmidt A, Singer W
Experience-dependent modifications of kitten striate cortex are not prevented by thalamic 
lesions that include the intralaminar nuclei
Exp Brain Res. 1988;70(3):627-31

Dudek SM, Bear MF
A biochemical correlate of the critical period for synaptic modification in the visual cortex
Science. 1989 Nov 3;246(4930):673-5

Gu QA, Bear MF, Singer W
Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation
Brain Res Dev Brain Res. 1989 Jun 1;47(2):281-8

Neve RL, Bear MF
Visual experience regulates gene expression in the developing striate cortex
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4781-4

Dudek SM, Bowen WD, Bear MF
Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes
Brain Res Dev Brain Res. 1989 May 1;47(1):123-8

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