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Mechanisms and regulation of naturally occurring synaptic plasticity in visual cortex

Ongoing projects are addressing the following questions:

• What is the primary cause of visual impairment after MD?  

• How does the visual cortex compensate for the loss of input from one eye?

• What mechanisms are responsible for changes in the qualities of OD plasticity over the lifespan?

• Can we exploit knowledge of LTP and metaplasticity to promote recovery of vision after
   long-term MD?

• What are the mechanisms and behavioral significance of stimulus-selective response
   potentiation (SRP), a possible synaptic substrate for recognition memory and perceptual learning?

• What are the mechanisms of response duration plasticity (RDP) that occurs in visual cortex when
   visual stimuli predict the timing of reward?




Sample of relevant recent papers: 


Chubykin AA, Roach EB, Bear MF, Shuler MG
A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex
Neuron. 2013 Feb 20;77(4):723-35


Cooper LN, Bear MF
The BCM theory of synapse modification at 30: interaction of theory with experiment
Nat Rev Neurosci. 2012 Nov;13(11):798-810


Cooke SF, Bear MF
Stimulus-Selective Response Plasticity in the Visual Cortex:
An Assay for the Assessment of Pathophysiology and Treatment of Cognitive Impairment Associated with Psychiatric Disorders
Biol Psychiatry. 2012 Mar 15;71(6):487-95.


Rachmuth G, Shouval HZ, Bear MF, Poon CS
A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49)
:E1266-74


Shepherd JD, Bear MF
New views of Arc, a master regulator of synaptic plasticity

Nat Neurosci. 2011 Mar;14(3):279-84


Cho KK, Bear MF
Promoting neurological recovery of function via metaplasticity
Future Neurol. 2010 Jan 1;5(1):21-26


McCurry CL, Shepherd JD, Tropea D, Wang KH, Bear MF, Sur M
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
Nat Neurosci. 2010 Apr;13(4):450-7


Khibnik LA, Cho KK, Bear MF
Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
Neuron. 2010 May 27;66(4):493-500


Cooke SF, Bear MF
Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex
J Neurosci. 2010 Dec 1;30(48):16304-13


Coleman JE, Nahmani M, Gavornik JP, Haslinger R, Heynen AJ, Erisir A, Bear MF
Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex
J Neurosci. 2010 Jul 21;30(29):9670-82


Smith GB, Heynen AJ, Bear MF
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67


Yoon BJ, Smith GB, Heynen AJ, Neve RL, Bear MF
Essential role for a long-term depression mechanism in ocular dominance plasticity
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9860-5


Linden ML, Heynen AJ, Haslinger RH, Bear MF
Thalamic activity that drives visual cortical plasticity
Nat Neurosci. 2009 Apr;12(4):390-2


Gavornik JP, Shuler MG, Loewenstein Y, Bear MF, Shouval HZ
Learning reward timing in cortex through reward dependent expression of synaptic plasticity
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6826-31


Coleman JE, Law K, Bear MF
Anatomical origins of ocular dominance in mouse primary visual cortex
Neuroscience. 2009 Jun 30;161(2):561-71

Cho KK, Khibnik L, Philpot BD, Bear MF
The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5377-82


Liu CH, Heynen AJ, Shuler MG, Bear MF
Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex
Neuron. 2008 May 8;58(3):340-5


Blais BS, Frenkel MY, Kuindersma SR, Muhammad R, Shouval HZ, Cooper LN, Bear MF
Recovery from monocular deprivation using binocular deprivation
J Neurophysiol. 2008 Oct;100(4):2217-24